Farmakokinetický profil, systémová toxicita a akutní účinky hexahydrokanabinolu (HHC) - animální studie.

Mallarino, Barbara

The emergence of semi-synthetic cannabinoids, exemplified by hexahydrocannabinol (HHC), poses a notable public health concern. Despite its growing popularity among cannabis users, HHC remains inadequately studied in both animal models and human subjects. To this day, only a few studies examining the drug's pharmacology, toxicology, and behavioral effects have been published. The present study therefore aims to delineate the pharmacokinetic profile, acute toxicity, and behavioral effects across a spectrum of dosages (1, 5, and 10 mg/kg, p.o.) in Wistar rats. Two hours after oral administration, the concentration of HHC peak in both blood serum and brain tissue. Toxicity was established according to the OECD toxicity assay, where HHC was categorized as a compound of class 4 toxicity, with an estimated lethal dose of 1 g/kg in a rat model. Further, HHC exhibited dose-dependent effects on locomotor activity and anxiety levels, since high doses induced a significant reduction in locomotor activity in the Open field test, concurrent with elevated anxiety. Moreover, HHC administration impaired sensorimotor gating, as evidenced by deficits in Prepulse Inhibition, with the severity of these effects correlating positively with dosage escalation. This thesis is one of the first studies focused on the acute...

host :: přihlásit Digitální repozitář
		Hledej		Nový záznam		Nápověda		O repozitáři