Original title: Electrochemical Properties of Pretomanid. New drug for Tuberculosis Treatment
Authors: Deri, M. ; Vespi, M. ; Giannarelli, S. ; Hromadová, Magdaléna
Document type: Papers
Conference/Event: Modern Electrochemical Methods /43./, Jetřichovice (CZ), 20240520
Year: 2024
Language: eng
Abstract: The electrochemical behavior of Pretomanid (PA 824) has been investigated in acetonitrile by cyclic voltammetry at different scan rates and compared to dimetridazole reduction in order to elucidate its redox mechanism. Both compounds show similar reduction behavior in the aprotic solvent that involves one electron transfer to the nitro group. The reduction of Pretomanid is more difficult and the stability of its nitro anion radical is much lower compared to the dimetridazole molecule.
Keywords: cyclic voltammetry; dimetridazole; pretomanid; reduction mechanism
Host item entry: Proceedings of the International Conference. 43rd Modern Electrochemical Methods, ISBN 978-80-908947-1-6

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available on demand via the digital repository of the Academy of Sciences.
Original record: https://hdl.handle.net/11104/0353812

Permalink: http://www.nusl.cz/ntk/nusl-615858


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Research > Institutes ASCR > J. Heyrovsky Institute of Physical Chemistry
Conference materials > Papers