Original title: Functional analysis of Ssc1 and Iba57 proteins in \kur{Trypanosoma brucei}
Translated title: Functional analysis of Ssc1 and Iba57 proteins in \kur{Trypanosoma brucei}
Authors: SKALICKÝ, Tomáš
Document type: Master’s theses
Year: 2011
Language: cze
Abstract: Aim of this thesis was to shed light on the function(s) of Iba57 and Ssc1 proteins in both life cycle stages of T. brucei using RNA interference. Depletion of Ssc1 resulted in severe grow phenotype, decrease in activities of iron-sulphur cluster-containing enzyme aconitase but no increase in oxidative stress sensitivity or accumulation of ROS in mitochondrion. Down regulation of Iba57, specialized maturation factor of aconitase and homoaconitase, lead to depletion of aconitase, destabilization of Isa1 and increased sensitivity to oxidative stress and accumulation of ROS in both stages.
Keywords: chaperone; Fe-S cllusters; functional analysis; Iba57; mitochondrion; oxidative stress; RNA interference; Ssc1; Trypanosoma brucei; chaperone; Fe-S cllusters; functional analysis; Iba57; mitochondrion; oxidative stress; RNA interference; Ssc1; Trypanosoma brucei
Citation: SKALICKÝ, Tomáš. Functional analysis of Ssc1 and Iba57 proteins in \kur{Trypanosoma brucei}. České Budějovice, 2011. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/16867

Permalink: http://www.nusl.cz/ntk/nusl-54886


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Master’s theses