Original title: Structural and functional characterization of the E3 ligase BIRC6
Authors: GRATZL, Sascha
Document type: Master’s theses
Year: 2023
Language: eng
Abstract: The aim of the thesis was to characterize the ubiquitin ligase BIRC6 in several contexts. The goal was to expand the knowledge on the selectivity of E1-E2 recognition, to increase the known substrate range of BIRC6, and to elucidate the molecular interactions fulfilled by BIRC6 during autophagy via interaction with GABARAP. In addition, it was aimed to gain a better understanding on the general ubiquitination mechanism in E2/E3 hybrid enzymes, to identify the ubiquitination sites of known apoptotic and autophagic substrates and to enlighten substrate recognition by BIRC6.
Keywords: AlphaFold2; apoptosis; ATG8; autophagy; cryo-EM; E3 ligase; inhibitor of apoptosis proteins; structural biology; ubiquitin; x-ray crystallography
Citation: GRATZL, Sascha. Structural and functional characterization of the E3 ligase BIRC6. České Budějovice, 2023. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/70104

Permalink: http://www.nusl.cz/ntk/nusl-538621


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Master’s theses