Original title: Study of the Role of mutations L39Q, L49Q, and N78T of Casein Kinase I epsilon in Breast Cancer Using \kur{Drosophila Melanogaster} as a Model Organism
Authors: KUBALA, Eugen
Document type: Bachelor's theses
Year: 2010
Language: eng
Abstract: [eng] [cze]
Several somatic mutations were found in human gene encoding Casein kinase I epsilon in breast cancer tissue samples. Since there is a homologue in Drosophila genome, discs overgrown locus that leads when mutated to hyperplastic overgrowth of imaginal wing discs, I attempted to obtain a Drosophila, which would carry one of the observed mutations in its genome. Ve vzorcích nádoru prsu bylo nalezeno několik somatických mutací genu Casein kinase I epsilon. Vzhledem k tomu, že genom Drosophily obsahuje homolog tohoto genu - discs overgrown locus, který, pokud je mutován, vede k hyperplastickému přemnožení imaginalních disků křídla - snažil jsem se získat jedince, který by nesl jednu z pozorovaných mutací CKI? ve svém genomu.
Citation: KUBALA, Eugen. Study of the Role of mutations L39Q, L49Q, and N78T of Casein Kinase I epsilon in Breast Cancer Using \kur{Drosophila Melanogaster} as a Model Organism. České Budějovice, 2010. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/20450

Permalink: http://www.nusl.cz/ntk/nusl-53413


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Bachelor's theses