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Original title:
Comprehensive analysis of putrescine metabolism in A thaliana using GWAS, genetic risk score, metabolic modelling and data mining
Authors: Schwarzerová, Jana ; Bartoň, Vojtěch ; Walther, Dirk ; Weckwerth, Wolfram
Document type: Papers
Language: eng
Publisher: Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
Abstract: Polyamines are known to be functionally involvedin plant responses to stress conditions. Despite a large amount ofphysiological and genetic data, the mode of action of polyamines,especially putrescine, at the molecular level still remains unclear.An increasing number of studies point to a role of putrescine instress defense of plants due to influencing the formation of reactiveoxygen species (ROS) in cellular stress conditions. Moreover,putrescine has been found to modulate abscisic acid (ABA)biosynthesis at the transcriptional level in response to lowtemperature, revealing a novel mode of action of polyamines asregulators of hormone biosynthesis. This study presents a newholistic approach towards the analysis of putrescine metabolismusing genome-wide association studies and the calculation ofgenetic risk scores extended by Boolean analysis in metabolitesnetwork as well as data mining from available databases andliterature. It can lead to a better understanding of biologicalprocesses involved in adaptation of plants to environmentalchanges.
Keywords: Diversification; Genetic Risk Score,The 1001 Genomes Project; GWAS; Reactive Oxygen Species
Host item entry: Proceedings II of the 29st Conference STUDENT EEICT 2023: Selected papers, ISBN 978-80-214-6154-3, ISSN 2788-1334
Institution: Brno University of Technology (web)
Document availability information: Fulltext is available in the Brno University of Technology Digital Library.
Original record: http://hdl.handle.net/11012/210679
Permalink: http://www.nusl.cz/ntk/nusl-531785
The record appears in these collections:
Universities and colleges > Public universities > Brno University of Technology
Conference materials > Papers
Authors: Schwarzerová, Jana ; Bartoň, Vojtěch ; Walther, Dirk ; Weckwerth, Wolfram
Document type: Papers
Language: eng
Publisher: Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
Abstract: Polyamines are known to be functionally involvedin plant responses to stress conditions. Despite a large amount ofphysiological and genetic data, the mode of action of polyamines,especially putrescine, at the molecular level still remains unclear.An increasing number of studies point to a role of putrescine instress defense of plants due to influencing the formation of reactiveoxygen species (ROS) in cellular stress conditions. Moreover,putrescine has been found to modulate abscisic acid (ABA)biosynthesis at the transcriptional level in response to lowtemperature, revealing a novel mode of action of polyamines asregulators of hormone biosynthesis. This study presents a newholistic approach towards the analysis of putrescine metabolismusing genome-wide association studies and the calculation ofgenetic risk scores extended by Boolean analysis in metabolitesnetwork as well as data mining from available databases andliterature. It can lead to a better understanding of biologicalprocesses involved in adaptation of plants to environmentalchanges.
Keywords: Diversification; Genetic Risk Score,The 1001 Genomes Project; GWAS; Reactive Oxygen Species
Host item entry: Proceedings II of the 29st Conference STUDENT EEICT 2023: Selected papers, ISBN 978-80-214-6154-3, ISSN 2788-1334
Institution: Brno University of Technology (web)
Document availability information: Fulltext is available in the Brno University of Technology Digital Library.
Original record: http://hdl.handle.net/11012/210679
Permalink: http://www.nusl.cz/ntk/nusl-531785
The record appears in these collections:
Universities and colleges > Public universities > Brno University of Technology
Conference materials > Papers
Record created 2023-07-23, last modified 2023-08-06