Vliv molekulové hmotnosti poly(I:C) na vývoj a chování potomstva v modelu mateřské imunitní aktivace

Cmarková, Nathalie

Maternal inflammation during pregnancy is associated with an increased risk of the development of psychiatric disorders in offspring, especially schizophrenia and autism. Prenatal treatment with poly(I:C), a viral mimetic, is a widely used model of maternal immune activation leading to developmental and behavioral alterations in offspring. However, results of studies are inconsistent possibly due to the differences in the molecular weight of used poly(I:C). In this thesis, the effect of different molecular weights of poly(I:C) was assessed. Pregnant Wistar rat females were treated by either high molecular weight (HMW) or low molecular weight (LMW) poly(I:C) on gestational day 14 to assess developmental and behavioral deficits relevant to schizophrenia and autism in offspring on postnatal day 12 and at three months. Prenatal exposition to the HMW poly(I:C) led to significantly reduced social behavior in the Homing test and a trend towards reduced USV vocalization in pups. The LMW pups showed significantly impaired negative geotaxis. In adulthood, the HMW and LMW offspring both exhibited significant social deficits and reduced anxiety. Anxiety was reduced mainly in the LMW group. This thesis revealed differences in behavioral outcomes between prenatal exposition to HMW and LMW poly(I:C). These...

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