Original title: Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds
Authors: Sokolová, Romana ; Jiroušková, Eliška ; Degano, I. ; Wantulok, J. ; Nycz, J.
Document type: Papers
Conference/Event: Moderní elektrochemické metody /42./, Jetřichovice (CZ), 20230522
Year: 2023
Language: eng
Abstract: The electron transfer reactions play an important role in many natural processes. Reactions such as \ndissociation, protonation, and reactions with water and other small molecules often occur in \nbiotransformation. The reaction schemes involving these chemical reactions coupled to the \nelectron transfer can be determined by cyclic voltammetry. Additionally, in \nsitu spectroelectrochemistry can efficiently contribute to the determination of oxidation or \nreduction mechanism. This technique provides information about the electroactive chromophore during \nthe redox process allowing to identification the first reaction intermediates. The final reaction \nproducts were identified by chromatographic techniques. This study represents a key role of TR \nspectroelectrochemistry in the determination of reaction intermediates in the case of \n1,10- phenanthroline derivative substituted by bioactive phenothiazine unit and \ndrug 3- fluorophenmetrazine (2-(3-fluorophenyl)-3-methylmorpholine, 3-FPM). Co pound 3-FPM\nhave recently appeared as the new psychoactive substance in the drug market.\n
Keywords: IR spectroelectrochemistry; oxidation mechanism; psychoactive substances
Host item entry: Moderní elektrochemické metody /42./. Sborník přednášek, ISBN 978-80-908947-0-9

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available on demand via the digital repository of the Academy of Sciences.
Original record: https://hdl.handle.net/11104/0343385

Permalink: http://www.nusl.cz/ntk/nusl-526222

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Research > Institutes ASCR > J. Heyrovsky Institute of Physical Chemistry
Conference materials > Papers
 Record created 2023-06-18, last modified 2024-02-25

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