Funkční propojení mezi lidskou tukovou tkání a lymfatickým systémem

Varaliová, Zuzana

Both adipose tissue (AT) and lymphatic system (LS) are organs with a great influence on whole-body homeostasis and metabolism. Although the first evidence of a link between the AT and LS was provided already in the 19th century when immune clusters called "milk spots" were found in the omental AT, their functional crosstalk remained unexplored and therefore unappreciated for a long time. However, research in recent years has begun to clearly demonstrate the relationship between the two organs, thanks to the development of new tools for studying and visualizing the LS. Nevertheless, many questions about this crosstalk remain unanswered. This doctoral thesis therefore aimed to answer some of them: How do AT and adipocytes change in response to LS dysfunction ranging from worsened lymphatic drainage to chronic lymphedema? What is the trigger of massive AT expansion in lymphedema? Do adipocytes support lymphangiogenesis, and how? Do lymphatic endothelial cells (LECs) affect the metabolic activities of adipocytes? Although our experiments to answer these questions are ongoing, this work demonstrates several new facts. We showed that the lack of effective lymphatic drainage affects lipolytic reactivity in femoral AT and leads to significant differences in the distribution of AT metabolites between the...

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