Original title: Reimplementation of the Connectivity Map with Accessibility Enhancements
Authors: ARICANLI, Evren
Document type: Bachelor's theses
Year: 2020
Language: eng
Abstract: The Connectivity Map (CMap) is a biomedical research tool which leverages modern biotechnology and bioinformatic methods to provide a platform for comparing the a subject gene expression profile against a library of drug-treatment gene expression profiles. This comparison allows for retrieval of drugs from the CMap's library which induce biological activity similar (or dissimilar) to a given subject expression profile -- thereby making it a tool which allows for the finding of repositionable drugs. Herein, a number of adaptations are proposed -- most focally being changes which would enhance the tool's accessibility (e.g. a simplified UI/workflow, expanded queryable gene identifiers). Using the R statistical computing environment and numerous libraries available through it, an adapted CMap tool was created from the publically-accessible CMap data, which housed the proposed adaptations. To evaluate success of the accessibility adaptations, the adapted CMap tool was focus tested on several participants -- which ultimately yielded great favor for the changes made, allowing them to be conclusively suggested for future iterations of the CMap.
Keywords: Connectivity Map; Custom Microarray CDFs; DNA microarrays; Drug Repositioning; Factor Analysis for Robust Microarray Summarization; Gene Expression Analysis; User Interface Accessibilty
Citation: ARICANLI, Evren. Reimplementation of the Connectivity Map with Accessibility Enhancements. České Budějovice, 2020. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/63009

Permalink: http://www.nusl.cz/ntk/nusl-517521


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Bachelor's theses