Original title: Anti-inflammatory and immunomodulatory activities of Ixodes ricinus salivary proteins
Authors: CHLASTÁKOVÁ, Adéla
Document type: Doctoral theses
Year: 2022
Language: eng
Abstract: Ticks are highly specialized obligate ectoparasites whose life cycle is fully dependent on obtaining a blood meal from a host. To prevent blood clotting and counteract the host's immune and wound healing responses, ticks secrete saliva, containing hundreds to thousands of proteins and non-proteins, into the feeding cavity. This thesis focuses on deciphering the function of three serpins (inhibitors of serine proteases) expressed in the salivary glands of the European tick Ixodes ricinus. Iripin-1, Iripin-3, and Iripin-8 were produced in the Escherichia coli expression system, and their effects on the immune response were evaluated using various in vitro assays and a mouse model of acute inflammation. Furthermore, the thesis involves one review article that summarizes the role of serpins in tick physiology and tick-host interaction.
Keywords: immune response; inflammation; Ixodes ricinus; serpin; tick saliva
Citation: CHLASTÁKOVÁ, Adéla. Anti-inflammatory and immunomodulatory activities of Ixodes ricinus salivary proteins. České Budějovice, 2022. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/51502

Permalink: http://www.nusl.cz/ntk/nusl-513644


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses