Original title: Role of queuosine tRNA modification in the parasitic protist \kur{Trypanosoma brucei}
Authors: KULKARNI, Sneha Sunil
Document type: Doctoral theses
Year: 2021
Language: eng
Abstract: This study analyzes the queuosine (Q) tRNA modification and the enzyme responsible for Q formation, the tRNA guanine transglycosylase (TGT), in the parasitic protist \kur{Trypanosoma brucei}. We describe the interdependence of Q modification and tRNA subcellular trafficking, and how these two factors regulate codon biased translation. The effect of Q on translation has serious implications in the virulence of the parasite inside the mammalian host.
Keywords: mitochondria; Queuosine; synonymous codon usage; tRNA guanine transglycosylase; tRNA modifications; tRNA traficking
Citation: KULKARNI, Sneha Sunil. Role of queuosine tRNA modification in the parasitic protist \kur{Trypanosoma brucei}. České Budějovice, 2021. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/45932

Permalink: http://www.nusl.cz/ntk/nusl-513518


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses