Original title:
Role of queuosine tRNA modification in the parasitic protist \kur{Trypanosoma brucei}
Authors:
KULKARNI, Sneha Sunil Document type: Doctoral theses
Year:
2021
Language:
eng Abstract:
This study analyzes the queuosine (Q) tRNA modification and the enzyme responsible for Q formation, the tRNA guanine transglycosylase (TGT), in the parasitic protist \kur{Trypanosoma brucei}. We describe the interdependence of Q modification and tRNA subcellular trafficking, and how these two factors regulate codon biased translation. The effect of Q on translation has serious implications in the virulence of the parasite inside the mammalian host.
Keywords:
mitochondria; Queuosine; synonymous codon usage; tRNA guanine transglycosylase; tRNA modifications; tRNA traficking Citation: KULKARNI, Sneha Sunil. Role of queuosine tRNA modification in the parasitic protist \kur{Trypanosoma brucei}. České Budějovice, 2021. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Institution: University of South Bohemia in České Budějovice
(web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia. Original record: http://www.jcu.cz/vskp/45932