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Original title:
Bioenergetic studies in the parasitic protist Trypanosoma brucei: functional characterisation of the mitochondrial FoF1-ATP synthase/ATPase complex
Authors: HIERRO YAP, Carolina
Document type: Doctoral theses
Year: 2021
Language: eng
Abstract: This Ph.D. thesis focuses on the functional characterisation of the mitochondrial FoF1-ATP synthase/ATPase complex in the parasitic protist Trypanosoma brucei, a eukaryotic system that enables the study of both operation modes of the complex in physiological settings. The results presented in this thesis are divided in four topics: (i) bioenergetics consequences of mitochondrial FoF1-ATP synthase deficiency in two life cycle stages of the parasite, with emphasis on the roles of subunits ATPaseTb1 and OSCP, (ii) changes in energy metabolism of bloodstream form parasites depleted of cardiolipin, (iii) role of the FoF1-ATP synthase dimerisation in mitochondrial biogenesis and bioenergetics, with focus on the functional characterisation of the dimer-specific subunit g in the insect stage of the parasite, and (iv) role of subunit OSCP in the structural and functional integrity of the FoF1-ATPase in trypanosomes lacking mitochondrial DNA (akinetoplastic).
Keywords: bioenergetics.; FoF1-ATP synthase/ATPase; mitochondria; Trypanosoma brucei
Citation: HIERRO YAP, Carolina. Bioenergetic studies in the parasitic protist Trypanosoma brucei: functional characterisation of the mitochondrial FoF1-ATP synthase/ATPase complex. České Budějovice, 2021. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/45930
Permalink: http://www.nusl.cz/ntk/nusl-513516
The record appears in these collections:
Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses
Authors: HIERRO YAP, Carolina
Document type: Doctoral theses
Year: 2021
Language: eng
Abstract: This Ph.D. thesis focuses on the functional characterisation of the mitochondrial FoF1-ATP synthase/ATPase complex in the parasitic protist Trypanosoma brucei, a eukaryotic system that enables the study of both operation modes of the complex in physiological settings. The results presented in this thesis are divided in four topics: (i) bioenergetics consequences of mitochondrial FoF1-ATP synthase deficiency in two life cycle stages of the parasite, with emphasis on the roles of subunits ATPaseTb1 and OSCP, (ii) changes in energy metabolism of bloodstream form parasites depleted of cardiolipin, (iii) role of the FoF1-ATP synthase dimerisation in mitochondrial biogenesis and bioenergetics, with focus on the functional characterisation of the dimer-specific subunit g in the insect stage of the parasite, and (iv) role of subunit OSCP in the structural and functional integrity of the FoF1-ATPase in trypanosomes lacking mitochondrial DNA (akinetoplastic).
Keywords: bioenergetics.; FoF1-ATP synthase/ATPase; mitochondria; Trypanosoma brucei
Citation: HIERRO YAP, Carolina. Bioenergetic studies in the parasitic protist Trypanosoma brucei: functional characterisation of the mitochondrial FoF1-ATP synthase/ATPase complex. České Budějovice, 2021. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/45930
Permalink: http://www.nusl.cz/ntk/nusl-513516
The record appears in these collections:
Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses
Record created 2023-01-15, last modified 2024-03-17