Original title: Biology of the Mitochondrial Contact Site and Cristae Organizing System in Trypanosomatids
Authors: KAUROV, Iosif
Document type: Doctoral theses
Year: 2019
Language: eng
Abstract: This study describes Mitochondrial Contact Site and Cristae Organizing System (MICOS) in unicellular parasitic protist Trypanosoma brucei. This is the first study of MICOS outside of canonical model organisms belonging to the supergroup Opisthokonta. Nine subunits of the complex were purified and characterized. Their role in cristae biogenesis and interaction with other mitochondrial protein complexes was demonstrated. Further investigation revealed a hierarchical organization of T. brucei MICOS and the existence of two subcomplexes. One of MICOS subunits, TbMic20, facilitates protein import into mitochondrial intermembrane space, which is one of the novel features of T. brucei MICOS. The role of TbMic20 in oxidative protein folding was demonstrated and the mechanism of this process in T. brucei was addressed.
Citation: KAUROV, Iosif. Biology of the Mitochondrial Contact Site and Cristae Organizing System in Trypanosomatids. České Budějovice, 2019. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/40986

Permalink: http://www.nusl.cz/ntk/nusl-513454


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses