Original title: Functional analysis of tick salivary serine and cysteine protease inhibitors
Authors: KOTÁL, Jan
Document type: Doctoral theses
Year: 2020
Language: eng
Abstract: The proposed thesis focuses on the characterization of two protease inhibitors present in tick saliva. More specifically, the thesis presents immunomodulatory properties, biochemical specificity and structure of a cysteine protease inhibitor named Iristatin. Another characterized protein, IRS-8, comes from a serpin family (serine protease inhibitors) and inhibits blood coagulation and complement system in the host. Furthermore, the thesis provides a literature overview and discussion of tick salivary molecules in the context of tick-host-pathogen interaction, vaccination potential and medicine potential. Two review manuscripts, which are part of this thesis summarize the effects of tick saliva and protease inhibitors on host immune mechanisms.
Keywords: coagulation; cystatin; immunity; protease inhibitor; saliva; serpin; tick
Citation: KOTÁL, Jan. Functional analysis of tick salivary serine and cysteine protease inhibitors. České Budějovice, 2020. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/39608

Permalink: http://www.nusl.cz/ntk/nusl-513437


The record appears in these collections:
Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses