Original title: Rozdíly v elektrochemické redukci jedno- a vícejaderných acylgermanů
Translated title: Differences in Electrochemical Reduction of Mono- and Polynuclear Acylgermanes
Authors: Šimková, Ludmila ; Dunlop, David ; Liška, Alan ; Ludvík, Jiří
Document type: Papers
Conference/Event: Moderní Elektrochemické Metody /40./, Jetřichovice (CZ), 20211108
Year: 2021
Language: cze
Abstract: [cze] [eng]
Derivaty titanocenu nachazeji bohate vyuziti jako katalyzatory pri cele fade chemickych\ntransformaci. Nicmene v posledni dobe se zkouma i jejich potencialni vyuziti jako cytostatik\npri lecbe onkologickych onemocneni. Nedavne studie poukazaly na vyssi cytotoxicitu u cele\nfady titanocen difluoridovych derivatu v porovnani s jejich dichloridovymi analogy.\nNasledne zkoumani mechanismu ucinku titanocemi poukazalo na rozpad endoplasmatickeho\nretikula rakovinnych bunek pusobenim reaktivnich kyslikovych castic (ROS). Tyto castice\ngenerovane pomoci redoxne aktivnich kovu (v nasem pripade titanocenu) muzou byt ucinnym\nprostredkem pro selektivni likvidaci rakovinovych bunek, jejichz homeostaza je na pritomnost\nROS citlivejsi V porovnani se zdravymi bunkami. Recently, titanocene derivatives have been investigated in term of their potential use as\ncytostatics in the treatment of oncological diseases. The potentials for reduction or oxidation of\nindividual substances are one of the key properties which fundamentally affect the cytostatic\nefficiency. Our previous results led us to investigate the redox properties of series of titanocene\ndifluoride and dichloride derivatives. This study is mainly focused on the effect of the\nsubstitution of cyclopentadienyl ring and the halide anion on the redox properties of the\nderivative.
Keywords: Substitution of cyclopentadienyl ring; Titanocene derivatives; Tuning of redox behavior
Project no.: GA17-05838S (CEP)
Funding provider: GA ČR
Host item entry: Sborník přednášek mezinárodní odborné konference XL. Moderní Elektrochemické Metody, ISBN 978-80-905221-8-3

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available on demand via the digital repository of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0325360

Permalink: http://www.nusl.cz/ntk/nusl-508283


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Conference materials > Papers