Srovnání různých druhů hlodavců jako hostitelů leishmanií patogenních pro člověka.

Vojtková, Barbora

6 ABSTRACT Leishmania parasites (Kinetoplastida: Trypanosomatidae) are causative agents of leishmaniases, a group of vector-borne diseases with various manifestations and complex epidemiology. Principal vectors are sand flies (Diptera: Psychodidae) and among mammalian hosts, rodents are predominantly represented. Rodents are also the most common laboratory models for the research of leishmaniases. However, reservoirs of most Leishmania species are still poorly recognized and the scope of standard model hosts is still insufficient to mimic well the wide spectrum of leishmaniases. This PhD thesis summarizes three different topics, all dealing with experimental infections of rodents with important human parasites - Leishmania major and L. donovani. The first topic was focused on the effect of sand fly saliva on the development of cutaneous leishmaniasis. BALB/c mice infected intradermally with L. major were repeatedly bitten by P. duboscqi females every two weeks. The multiple and repeated sand fly bites significantly enhanced the development of cutaneous lesions and increased parasite load. The second topic was aimed at enrichment of the spectrum of laboratory model animals for Leishmania research. Three Asian rodent species (Cricetulus griseus, Lagurus lagurus and Phodopus sungorus) were infected with L....

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