Molekulární analýza somatických a zárodečných mutací a morfologické aspekty neobvyklých variant maligních melanomů a melanocytárních lézí

Donati, Michele

Somatic and germline molecular analysis and morphological aspects of unusual variants of malignant melanomas and uncommon melanocytic neoplasms Abstract Background: The histopathological diagnosis of melanocytic tumors represented one of the greatest challenges of pathology. In the last years, the concept of melanoma as a single entity have been questioned. In fact, several subgroups of melanocytic neoplasms have been recognized on the bases of their clinical and histological presentation. The microscopic assessment of these lesions is based upon the detection of a constellation of morphological features, some of which lack interobserver reproducibility. In recent years, thanks to the development of molecular biology, a significant step forward has been made in the diagnosis of melanocytic neoplasms. Considering clinicopathological and genetic data some authors have suggested a stepwise model of evolution of melanocytic neoplasm to melanoma from a conventional nevus. Moreover, in the era of precision medicine, several efforts are being made to identify molecular biomarkers to predict prognosis. These biomarkers can be detected also in germline status of the patients to identify predisposing factors to tumor development. Aims: Primary aim of our projects is to perform of molecular analysis on morphologically...

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