Original title: Metaloproteinázy mezibuněčné matrix v předním očním segmentu
Translated title: Matrix metalloproteinases in anterior eye segment
Authors: Paračková, Zuzana ; Ardan, Taras (advisor) ; Paňková, Daniela (referee)
Document type: Bachelor's theses
Year: 2011
Language: slo
Abstract: [eng] [cze]
Matrix metalloproteinases belong to the group of proteases which in normal tissue are responsible for degradation a and remodeling of extracellular matrix components and their activity is regulated by endogenous inhibitors. However, many patological conditions of the anterior eye segment are characterized by increased activity of matrix metalloproteinases and conversely decreased activity of their tissue inhibitors.The imbalance between matrix metalloproteinases and their inhibitors can lead to destructive proteolytic tissue damage anterior eye segment, including blindness. Key words: matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases, extracellular matrix Metaloproteinázy medzibunkovej matrix patria ke skupine proteáz, ktoré v normálnom tkanive sú zodpovedné za degradáciu a remodeláciu jednotlivých komponent medzibunkovej matrix a ich aktivita je regulovaná endogénnymi inhibítormi. Avšak mnohé patologické stavy predného očného segmentu sú charakterizované zvýšenou aktivitou metaloproteináz medzibunkovej matrix a naopak zníženou aktivitou ich tkanivových inhibítorov. Nerovnováha medzi metaloproteinázami medzibunkovej matrix a ich inhibítormi môže viesť k deštruktivnému proteolytickému poškodeniu tkaniva predného segmentu oka, vrátane straty zraku. Kľúčové slova: metaloproteinázy medzibunkovej matrix, tkanivové inhibítory metaloproteináz medzibunkovej matrix, extracelulárna matrix
Keywords: extracellular matrix; matrix metalloproteinases; tissue inhibitors of matrix metalloproteinases; extracelulárna matrix; metaloproteinázy medzibunkovej matrix; tkanivové inhibítory metaloproteináz medzibunkovej matrix

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/36684

Permalink: http://www.nusl.cz/ntk/nusl-476281


The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Bachelor's theses