Zpracování informace o sociálních interakcích hipokampálními neurony potkana.

Hanzlík, Adam-František

ABTRACT In order to survive, an animal must be able to integrate vital information about it's surroundings, such as information about the environment and the social interactions therein. Decades of research have established the hippocampal formation as a structure indispensable for spatial memory. It was only recently, though, that evidence has emerged suggesting that the hippocampus, most notably the dorsal CA2 region, also supports the encoding of social information. New behavioural as well as electrophysiological evidence appeared, highlighting the importance of sleep for the processing of social information. In my thesis, I used microelectrodes to record the electrophysiological activity of individual CA2 neurons from freely-moving rats, during wake as well as in sleep. In order to study the processing of social information by hippocampal neurons, I employed a novel experimental paradigm in which social stimulation, in the form of two rat conspecifics, was presented in a spatial context. I report that the discharge of some CA2 neurons was organised within the experimental maze, even after social stimulation was added. Moreover, I observed that the spatial activity of neurons changed after the addition of social stimuli, and that it further changed when the location of the two conspecifics was shuffled....

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