Original title: Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte
Authors: Ohlidalova, D. ; Pásek, Michal ; Šimurda, J. ; Christé, G.
Document type: Papers
Conference/Event: BIOSIGNAL, Brno (CZ), 2010-06-27 / 2010-06-29
Year: 2010
Language: eng
Abstract: A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation.
Keywords: cardiac cell; quantitative model; transverse-axial tubular system
Project no.: CEZ:AV0Z20760514 (CEP)
Host item entry: Analysis of biomedical signals and images, ISBN 978-80-214-4106-4, ISSN 1211-412X

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0191500

Permalink: http://www.nusl.cz/ntk/nusl-42157


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Research > Institutes ASCR > Institute of Thermomechanics
Conference materials > Papers