Original title: Utilization of Catalytic Hydrogen Evolution in Electrochemical Analysis of Nucleic Acids
Authors: Fojta, Miroslav ; Daňhel, Aleš ; Špaček, Jan ; Havran, Luděk ; Šebest, Peter ; Orság, Petr ; Pivoňková, Hana ; Vosáhlová, J. ; Schwarzová-Pecková, K.
Document type: Papers
Conference/Event: Moderní elektrochemické metody /37./, Jetřichovice (CZ), 20170515
Year: 2017
Language: eng
Abstract: Catalysis of hydrogen evolution (CHE) at mercury in the presence of proteins was discoverd shortly after the introduction of polarography. In contrast, unmodified nucleic acids have not been reported to produce distinct signals due to the CHE to date. Chemically modified nucleic acids bearing certain extrinsic groups produce analytically useful signals due to hydrogen evloution catalyzed by the respective modifications. These species include (a) transition metal complexes, and (b) non-metal catalytically active organic moieties. In addition, the CHE has been reported to be invoved in guanine reduction process at the mercury-based electrodes.
Keywords: Amalgam; Catalytic hydrogen evolution; Mercury
Project no.: GBP206/12/G151 (CEP), EF15_003/0000477
Funding provider: GA ČR, GA MŠk
Host item entry: XXXVII. Moderní elektrochemické metody. Sborník přednášek mezinárodní odborné konference, ISBN 978-80-905221-5-2

Institution: Institute of Biophysics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0297841

Permalink: http://www.nusl.cz/ntk/nusl-399147

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Research > Institutes ASCR > Institute of Biophysics
Conference materials > Papers
 Record created 2019-08-26, last modified 2020-03-27

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