Original title: New Ligands for Modification of DNA by Osmium Tetroxide Reagents
Authors: Havran, Luděk ; Zenka, Martin ; Fojta, Miroslav
Document type: Papers
Conference/Event: Moderní elektrochemické metody /36./, Jetřichovice (CZ), 20160523
Year: 2016
Language: eng
Abstract: Besides DNA intrinsic electroactivity, modification of DNA by redox active tags find wide use in electrochemical analysis of DNA interactions and damage. Application of these tags can improve specificity of the analysis. One from utilized labels in this field are complexes of osmium tetroxide with nitrogen ligands, which produce with DNA electroactive covalent adducts. These complexes preferentially react with thymine in single strand DNA. Type of used ligand influence electrochemical behavior forming adducts. In this contribution will be presented results which are acquired by testing of set a new ligands based of quinone and substituted 1, 10-phenanthroline.
Keywords: complexes; dna; nucleic-acids; Osmium tetroxide complexes
Project no.: GBP206/12/G151 (CEP)
Funding provider: GA ČR
Host item entry: XXXVI. Moderní elektrochemické metody. Sborník přednášek, ISBN 978-80-905221-4-5

Institution: Institute of Biophysics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0297880

Permalink: http://www.nusl.cz/ntk/nusl-396405


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Research > Institutes ASCR > Institute of Biophysics
Conference materials > Papers