Original title: Phenotypic Analyses of the HD Transgenic Minipig Model (A11609)
Authors: Ellederová, Zdeňka
Document type: Research reports
Year: 2018
Language: eng
Abstract: The transgenic Huntington's disease minipigs (TgHD) express N‐terminal part of human mutated huntingtin (124Q) under the control of human huntingtin promoter. The founder animal, born in 2009, gave birth to four subsequent generations with an equal contribution of wild‐type (WT) and transgenic (TgHD) piglets in all litters. The model is being used for preclinical huntingtin lowering studies. Here we take different non-invasive and invasive approaches, some of which are unique for large animal models, to study the phenotype development comparing WT and TgHD siblings. We show gradual progression of the disease in these TgHD animals. Moreover, some biomarkers were identified. These markers could serve for monitoring of organism response to HD treatment to assess efficacy and safety in preclinical studies prior to human clinical trials.
Keywords: minipig
Project no.: LO1609 (CEP)
Funding provider: GA MŠk

Institution: Institute of Animal Physiology and Genetics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0293534

Permalink: http://www.nusl.cz/ntk/nusl-392799


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Research > Institutes ASCR > Institute of Animal Physiology and Genetics
Reports > Research reports