Original title: Effect of nanodiamond particles on neuronal tissue
Authors: Šimková, Veronika ; Benson, Veronika
Document type: Papers
Conference/Event: Instruments and Methods for Biology and Medicine 2018, Kladno (CZ), 20180510
Year: 2018
Language: eng
Abstract: High-Pressure High-Temperature nanodiamonds are considered to be highly biocompatible due to\ntheir low acute toxicity, which makes them suitable for biomedical applications. However, next to interaction with the cell membrane, nanoscale allows particles to penetrate the plasma membrane and even accumulate in the cell cytoplasm. Recently it brought up questions regarding sustainable nanoparticle application in vivo and potential toxicity hazards. The neuronal tissue consists of neurons and glial cells, and it is separated by a bloodbrain barrier from the peripheral blood system. Neurons are nerve cells forming a complex network of synapses that carry signals in the brain. The neurons are nourished and protected by glial cells. This project aims to find out whether nanodiamonds pass the blood-brain barrier when applied intravenously as a drug carrier and whether they directly interact with the neuronal tissue.
Keywords: cell cytoplasm; nanodiamonds; neuronal tissue
Host item entry: IMBM 2018 Proceedings, ISBN 978-80-01-06502-0

Institution: Institute of Microbiology AS ČR (web)
Document availability information: Fulltext is available on demand via the digital repository of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0292238

Permalink: http://www.nusl.cz/ntk/nusl-391551


The record appears in these collections:
Research > Institutes ASCR > Institute of Microbiology
Conference materials > Papers