Original title:
Vliv vrozených hyperkoagulačních stavů na hladinu D-d se zaměřením na gravidní ženy
Authors:
ŠTÍCHOVÁ, Zuzana Document type: Master’s theses
Year:
2017
Language:
cze Abstract:
The thesis analyses the female patients' data from Clinical hematology department in České Budějovice hospital from year 2014 to 2015 and tries to statistically confirm connection between D-dimer level and hypercoagulable states described in previous bachelor thesis. D-dimer assay is due to negative predictive value and high sensitivity an initial laboratory test to rule out tromboembolic disease. However, it has low specificity. The elevated level of D-dimer is observed in conditions like infection, trauma, acute cancer, recent surgery or pregnancy and last studies showed increased D-dimer level even in combination with inherited hypercoagulable states. Thus, it is necessary to analyse the level of D-dimer in pregnant women related to specific hypercoagulable states. Moreover, the thesis analyses the influence of other factors like anticoagulation therapy on D-dimer level and tries to find connection between D-dimer level and pregnancy associated complication, birth weight or a type of delivery.
Keywords:
D-dimer; hypercoagulable states; pregnancy; thrombophilia; venous thromboembolism; D-dimery; gravidita; hyperkoagulační stav; Leidenská mutace; tromboembolická nemoc; trombofilie Citation: ŠTÍCHOVÁ, Zuzana. Vliv vrozených hyperkoagulačních stavů na hladinu D-d se zaměřením na gravidní ženy. České Budějovice, 2017. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Institution: University of South Bohemia in České Budějovice
(web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia. Original record: http://www.jcu.cz/vskp/48537