Original title: The role of RNA-binding proteins in post-transcriptional gene regulation of Trypanosoma brucei
Authors: DIXIT, Sameer
Document type: Doctoral theses
Year: 2018
Language: eng
Abstract: This thesis characterizes RNA footprints of several RNA-binding proteins (RBPs) thatare involved in U-insertion/deletion, A-to-I, and C-to-U RNA editing in Trypanosoma brucei. Relying on iCLIP data and biochemical methods it shows that two paralogs proteins from the MRB1 complex regulate distinct editing fates of the mitochondrial transcripts. Further, this thesis provides evidence where the combinatorial interplay of RBPs might fine-tune the levels of edited mRNA. Finally, the presented thesis adds to the growing evidence of the importance of RBPs in post-transcriptional gene regulation.
Keywords: iCLIP; mitochondrial RNA biology; Post-trancriptional gene regulation; RNA editing
Citation: DIXIT, Sameer. The role of RNA-binding proteins in post-transcriptional gene regulation of Trypanosoma brucei. České Budějovice, 2018. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/30994

Permalink: http://www.nusl.cz/ntk/nusl-371664


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses