Original title: A MODIFIED MATHEMATICAL MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE INCORPORATING SEPARATE T-TUBULAR AND SURFACE DYADS AND SUBMEMBRANE SPACES
Authors: Pásek, Michal ; Bébarová, M. ; Christé, G.
Document type: Papers
Conference/Event: Engineering Mechanics 2017, Svratka (CZ), 20170515
Year: 2017
Language: eng
Abstract: Intracellular Ca2+ load and Ca2+ transient are considerably dependent on distribution of sarcolemmal Ca2+ pump and Na+-Ca2+ exchanger between the t-tubular and surface membranes in the presence of separate dyadic and subsarcolemmal spaces in rat ventricular cell model. To explore analogical phenomenon in human, we modified our previously published model of human ventricular myocyte. When the t-tubular fractions of Na+-Ca2+ exchanger and of sarcolemmal Ca2+ pump were increased to the newly proposed value of 0.95 in the modified model, the following changes were observed at 1 Hz steady-state stimulation: a shortening of the action potential duration at 90% repolarisation by 6% and an increase of the cytosolic Ca2+ transient by 22%. Further analysis revealed a critical role of Ca2+ concentration changes in the subsarcolemmal spaces and consequent change in cellular Ca2+ cycling in this effect.
Keywords: calcium cycling; dyads; human ventricular cell model; subsarcolemmal spaces; t-tubules
Host item entry: Engineering Mechanics 2017, ISBN 978-80-214-5497-2, ISSN 1805-8248

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0279791

Permalink: http://www.nusl.cz/ntk/nusl-371432


The record appears in these collections:
Research > Institutes ASCR > Institute of Thermomechanics
Conference materials > Papers