Original title: Studium nádorové imunoterapie založené na instalaci ligandů fagocytárních receptorů na nádorové buňky a objasnění probíhajících procesorů
Authors: CAISOVÁ, Veronika
Document type: Doctoral theses
Year: 2017
Language: cze
Abstract: [cze] [eng]
Imunoterapie se zda jako velmi efektivni lecba nadorovych onemocneni. Pri tomto typu terapie jsou nadorove bunky eliminovany telu vlastnimi imunitnimi bunkami s minimalnim negativnim efektem na zdravou tkan. Tato prace je zamerena na imunoterapii zalozenou na aktivaci vrozene imunity, konkretne na intratumoralni aplikaci fagocytozu stimulujicich ligandu a ligandu Toll-like receptoru. Tento terapeuticky pristup byl testovan u nekolika druhu nadorovych mysich modelu - melanom B16-F10, pankreaticky adenokarcinom a pheochromocytom. Slozeni terapeuticke smesi a davkovani terapeuticke smesi bylo optimalizovano v ramci teto prace. Zaroven byly zkoumany mechanismy zapojene v eliminaci nadoru v prubehu teto terapi. Immunotherapy became a very promising approach for cancer therapy. Tumor cells are eliminated using the body's own immune system with minimal negative effect on healthy tissue. This thesis is focused on immunotherapy based on activation of innate immunity, specifically on intratumoral application of ligands stimulating phagocytosis and Toll-like receptor ligands. This therapeutic approach was tested in several types of tumor mouse models, such as melanoma B16-F10, pancreatic adenocarcinoma, and pheochromocytoma. The composition of the therapeutic mixture as well as the application schedule were optimized in our studies. Subsequently the underlying mechanisms involved in tumor elimination during this therapy were investigated.
Keywords: immunotherapy; innate immunity; mouse tumor models; neutrophils; phagocytosis stimulating ligands; toll-like receptors ligands; tumors; immunoterapie; ligandy stimulujici fagocytozu; ligandy toll-like receptoru; mysi nadorove modely; nadory; neutrofily; vrozena imunita
Citation: CAISOVÁ, Veronika. Studium nádorové imunoterapie založené na instalaci ligandů fagocytárních receptorů na nádorové buňky a objasnění probíhajících procesorů. České Budějovice, 2017. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/39613

Permalink: http://www.nusl.cz/ntk/nusl-370739


The record appears in these collections:
Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses