Original title: The effect of perphenazine on transient outward potassium current in rat ventricular myocytes
Translated title: Účinek perphenazinu na přechodný draslíkový proud u komorových buněk potkana
Authors: Bébarová, M. ; Matejovič, P. ; Pásek, Michal ; Račkauskas, G. ; Šimurdová, M. ; Šimurda, J. ; Nováková, M.
Document type: Papers
Conference/Event: Biosignal 2006, Brno (CZ), 2006-06-28 / 2006-06-30
Year: 2006
Language: eng
Abstract: [eng] [cze]
The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 µmol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 µmol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction. Práce se zabývá vyšetřením účinku psychofarmaka perphenazinu na přechodný draslíkový proud u srdečních komorových buněk potkana.
Keywords: perphenazin; rat ventricular myocytes; transient outward current
Project no.: CEZ:AV0Z20760514 (CEP), GA305/04/1385 (CEP)
Funding provider: GA ČR
Host item entry: Analysis of Biomedical Signals and Images, ISBN 80-214-3152-0, ISSN 1211-412X

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0136091

Permalink: http://www.nusl.cz/ntk/nusl-35698


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