Original title: Molekulární epidemiologie a vlastnosti bakteriálních původců infekcí plic u pacientů s cystickou fibrózou
Translated title: Molecular epidemiology and characteristics of bacterial pathogens on lung infection in patients with cystic fibrosis
Authors: Vošahlíková, Šárka ; Nemec, Alexandr (advisor) ; Melter, Oto (referee) ; Osička, Radim (referee)
Document type: Doctoral theses
Year: 2014
Language: cze
Abstract: [cze] [eng]
Univerzita Karlova v Praze 2. lékařská fakulta Autoreferát dizertační práce Molekulární epidemiologie a vlastnosti bakteriálních původců infekcí plic u pacientů s cystickou fibrózou RNDr. Šárka Vošahlíková Praha (2014) 2 Vnitřní strana obálky: Doktorské studijní programy v biomedicíně Univerzita Karlova v Praze a Akademie věd České republiky Obor: Molekulární a buněčná biologie, genetika a virologie Předseda oborové rady: Prof. RNDr. Stanislav Zadražil, DrSc. Školicí pracoviště: Laboratoř molekulární genetiky, 2. lékařská fakulta, Univerzita Karlova v Praze Laboratoř bakteriální genetiky, Centrum epidemiologie a mikrobiologie, Státní Zdravotní Ústav, Praha Autor: RNDr. Šárka Vošahlíková Školitel: Doc. RNDr. Alexandr Nemec, Ph.D. Oponenti: Autoreferát byl rozeslán dne: Obhajoba se koná dne: ……………..v ………..hod. kde: …………………… S dizertační prací je možno se seznámit na děkanátu 2. lékařské fakulty Univerzity Karlovy v Praze. 3 Obsah 2. ABSTRAKT................................................................................................................................... 4 3. ABSTRACT ................................................................................................................................... 5 4. ÚVOD... Cystic fibrosis is the most abundant inherited autosomal recessive disease in Caucasian population. Cystic fibrosis is caused by a dysfunction of a transport channel which is responsible for the transport of chloride ions on the apical side of the plasma membrane. Despite the fact that the dysfunction of the transport channel is present in several organs, the most severely affected one is the respiratory system. Because of the ion imbalance, thick sticky mucus is produced on the surface of the airways which then prevents the removal of dust particles and bacteria. The main complications of cystic fibrosis are the bacterial infections of the respiratory system which become chronic during the patient's life and thus are the most common causes of the respiratory failure and premature death. The most important agents causing these infections are Pseudomonas aeruginosa and Burkholderia cepacia (Bcc). Infections caused by those bacteria are practically untreatable and serious complications arise from the existence of epidemic strains which can be transfered from patient to patient. Precise and fast diagnostics of pathogenic strains is a critical step to avoid spreading bacterial infections as well as strictly followed anti- epidemic strategies mainly based on isolation of cystic fibrosis patients according to...

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/67033

Permalink: http://www.nusl.cz/ntk/nusl-336168


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Academic theses (ETDs) > Doctoral theses