Role vybraných markerů v biologickém chování karcinomu mléčné žlázy

Gojiš, Ondřej

The role of selected molecules in biologic behaviour of human breast cancer Abstract Ondřej Gojiš In human breast cancer the rate of immunohistochemical discordance between primary tumour and secondary deposits were reported to range from 28% - 42% for ER and was 17% for PgR. Depending on the study and techniques utilized, discordance rates of Her2 ranged between 0% - 37%. It has been showed that PAX2 competes with SRC-3 for binding and regulation of HER-2 transcription. Human breast cancers that were PAX2 positive and SRC-3 negative had the lowest recurrence rate, and the relationship between PAX2 and SRC-3, with regard to levels that determine relapses, were found to be inversely dependent. This suggests a transcriptional link between the two subtypes of breast cancer, namely ER positive and HER2 positive tumors. Immunohistochemical profiles were performed for 30 metastatic deposits using antigens for SRC3, Pax2, ER, PgR, Her2, CK5/6, Ki67 and EGFR. SRC-3 was positive in 66.6% of cases and Pax2 in 73.3%. No correlation was observed between the patient's age, cancer grade, histotype, lymphatic node status, and protein expression. Using all seven antigens, the primary tumor's protein expression differed from that of the brain deposits in 13 cases out of 14 (93%). Constant expression of SRC3 and Pax2 was...

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