Original title: Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II
Authors: Pásek, Michal ; Christé, G. ; Šimurda, J.
Document type: Papers
Conference/Event: Engineering Mechanics 2003, Svratka (CZ), 2003-05-12 / 2003-05-15
Year: 2003
Language: eng
Abstract: In this work, we present a new version of cardiac ventricular cell model incorporating the transverse - axial tubular system. The improvements include reformulated description of L-type Ca2+ channel, of Ca2+ induced Ca2+ release from sarcoplasmic reticulum, of intracellular Ca2+ buffering and incorporation of potassium currents Ito, IK(Na) and IK(ATP). In comparison with the previous model (Pásek et al., 2002), the steady state simulations revealed more profound changes of tubular ionic concentration (12.8 % for Ca2+ and 4.7 % for K+ at 1 Hz). The refined model will be used for more exact quantitative exploration of the effect of transverse - axial tubular system on cellular electrical activity and excitation - contraction coupling.
Keywords: cardiac cell; quantitative modelling; tubular system
Project no.: CEZ:AV0Z2076919 (CEP), GP204/02/D129 (CEP)
Funding provider: GA ČR
Host item entry: Engineering mechanics 2003, ISBN 80-86246-18-3

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0107950

Permalink: http://www.nusl.cz/ntk/nusl-31559


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