Original title: Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells under low [K+]e
Authors: Pásek, Michal ; Christé, G. ; Šimurda, J.
Document type: Papers
Conference/Event: Biosignal 2002, Brno (CZ), 2002-06-26 / 2002-06-28
Year: 2002
Language: eng
Abstract: In this work, we explored quantitatively the effect of ion concentration changes in the restricted space of transverse-axial tubular system (TAT-system) on ventricular cell arrhythmogenesis under the conditions of low extracellular potassium concentration ([K+]e). The simulations were performed on a model that integrates the quantitative description of electrical activity of surface and tubular membrane with the quantitative description of dynamic changes of intracellular ion concentrations. The results predict that the TAT-system plays a significant protecting role in cellular arrhythmogenesis that arises from the enhancement of potassium concentration gradient between tubular and extracellular spaces at low level of [K+]e.
Keywords: cardiac cell; quantitative modelling; transverse-axial tubular system
Project no.: CEZ:AV0Z2076919 (CEP), CEZ:MSM 141100004
Host item entry: Analysis of biomedical signals and images, ISBN 80-214-2633-0, ISSN 1211-412X

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0107739

Permalink: http://www.nusl.cz/ntk/nusl-31445


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Research > Institutes ASCR > Institute of Thermomechanics
Conference materials > Papers