Original title: Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells: development of model
Authors: Pásek, Michal ; Christé, G. ; Šimurda, J.
Document type: Papers
Conference/Event: National conference with international participation Engineering mechanics, Svratka (CZ), 2002-05-13 / 2002-05-16
Year: 2002
Language: eng
Abstract: The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. In our previous work [27], the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised. In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed description of mechanisms controlling the intracellular and tubular ion concentrations.
Keywords: cardiac cell; quantitative modelling; transverse-axial tubular system
Project no.: CEZ:AV0Z2076919 (CEP)
Host item entry: Inženýrská mechanika 2002, ISBN 80-214-2109-6

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0107738

Permalink: http://www.nusl.cz/ntk/nusl-31444


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