Original title: Genetické aspekty Crohnovy choroby
Translated title: Genetic aspects of Crohn's disease
Authors: Hradský, Ondřej ; Cinek, Ondřej (advisor) ; Petřek, Martin (referee) ; Hubáček, Jaroslav (referee)
Document type: Doctoral theses
Year: 2011
Language: cze
Abstract: [cze] [eng]
J..mosmmkmý "'I/hm ,'ld/in4 u c"""""",, choroby (CO) byla nalez""" asoc:ia"" s II""Y 1/002, ATG/5I.! , IL2JR, Ioluoem 1005 a dali...; gen)' LOoahuji<"'; <10 In....."i <>.\ém věk u jsme vyieo';Ii vanOA v ll<"" TNFA Ukázal jsme vysokou frek""",,; m_i ~ HKl7" v III'fHJ 101002 v ieN;; popuIm. jeji ~ Vliv na YH: v dobti diac}nÓZy iWo ileáini Iormy """"""",j. NltŠe pni"" lak'; poapIoIypÓ CTU4 b)i pa!mj po _tft oci dle _oo.i JednosmmJw.ý SOWlrn vanglitrlné Crohn'. _ oe (COl h.. been ohown ..._Ied YIiIh Ihe variant. o, NOD2, ATGI51.! ond IL23R gene. , o, Ihe IB051<>1:...... _ .. o, oIher gene> 0,_ in the irnm..... respoooe_ T"" ~cies <>f Ihe von..l> pro!oundIy f the IB05 Iocu. _ ClU_ gene .. de",Iopm",,' ol Crohn'. .. the N002, ATGI51.! , 1L2JR, TIIFA _ PTPl/22 gene roI V3t\aI1" in IBOS _ CTLH d"romooomol fegions wiIh ped;atric-on...' and odul-onoet co .. ..., C,ecl> """"",boo. The ge_, phenoly;>o, _ . _ Irequencies '01<= compeon found .. NOD2 gene (1fIret> V_I, loIowed by "'" v_nto o, 1B05 1<>1:.... (IGR206Jb_ ' , ,.65960151, _.~'" asoociotion YIiIh vorian1 .. 1L23R ond ATGlfiLl _ , _ "" ~ .osoc:i3tion,.,.. _for the p.R62OW vofi.ant .. the PTPN22 ge"" or forthe 9_2306G>A variant .. the TIIFA gene. We hove rep popuIrioo _ . otrong e!leC1 ol """ alele on " e _ .1 diagnoo.ia ond .,.. Iofm ol

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/44622

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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses