Original title:
Změny exprese a signálních proteinů a genů v souvislosti s diabetickou nefropati í
Translated title:
Změny exprese signálních proteinů a genů v souvislosti s diabetickou nefropatií
Authors:
Demová, Hana ; Černá, Marie (advisor) ; Viklický, Ondřej (referee) ; Kalousová, Marta (referee) Document type: Doctoral theses
Year:
2011
Language:
eng Abstract:
[eng][cze] Hypothesis: I have investigated specific molecular and cell mechanisms that might be involved in the ethiopatogenesis of diabetic nephropathy. Their involvement might also be demonstrated in response to treatment of diabetic nephropathy. Aims: I have studied changes of signal transduction proteins (CAV-1, VEGF, RhoA) in renal cortical cells in the rat model of renal hypertension and in the rat model of type 1 diabetes. I also have performed analyses of polymorphisms in the genes involved in cell signaling with respect to their function in human study. Methods : The renal cortical expression of molecular targets CAV-1, VEGF, and RhoA have been assessed in addition to measurements of renal functional parameters in L-NAME-treated rats with or without a concomitant administration of atorvastatin (ATO) and have been compared to untreated control animals.Práce je věnována průzkumu změn exprese signálních proteinů a genů v souvislosti s diabetickou nefropatií na krysím modelu. Zjištění specifických molekulárních a buněčných mechanismů a jejich zapojení do etiopatogeneze diabetické nefropatie může mít i významný vliv na zkoumání reakcí při léčbě diabetické nefropatie.
Institution: Charles University Faculties (theses)
(web)
Document availability information: Available in the Charles University Digital Repository. Original record: http://hdl.handle.net/20.500.11956/35266