Original title:
Deriváty rhodaninu jako potenciální léčiva III
Translated title:
Derivatives of Rhodanine as Potential Drugs III
Authors:
Kalafutová, Stanislava ; Zimčík, Petr (referee) ; Opletalová, Veronika (advisor) Document type: Master’s theses
Year:
2009
Language:
slo Abstract:
[eng][cze] Diploma thesis Rhodanine derivatives as potential drugs III. Stanislava Kalafutová In the first part of the diploma thesis there is generally written about different types of tuberculosis in the various aspects as ethiology, pathogenesis and pharamacotherapy. The second part is focused on the newly tested potential antituberculotic drugs. Especially in the third part there are mentioned different drug targets of these promising antituberculotics. Finally the fourth part of the theoretical introduction briefly summarizes currently used drugs in the treatment of this infectous disease. The experimental work deals with number of synthesis of following compounds: 5-(3-bromobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(2- bromobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(3-chlorobenzylidene)-2- thioxo-1,3-thiazolidine-4-one, 5-(2-chlorobenzylidene)-2-thioxo-1,3-thiazolidine- 4-one, 5-(4-fluorobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(3- fluorobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(2-fluorobenzylidene)-2- thioxo-1,3-thiazolidine-4-one, 5-(pyridine-4-ylmetylidene)-2-thioxo-1,3- thiazolidine-4-one, 5-(pyridine-3-ylmetylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(furane-2-ylmetylidene)-2-thioxo-1,3-thiazolidine-4-one. All synthesized compounds were tested for an antifungal and antibacterial...7.ABSTRAKT Univerzita Karlová v Prahe, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutickej chémie a kontroly liečiv Diplomová práca Deriváty rodanínu ako potenciálne liečiva III. Stanislava Kalafutová V tejto diplomovej práci je v prvej časti teórie rozobraná tuberkulóza ako choroba vrátane etiológie, patogenézy, delenia tuberkulóz a terapie. Druhá časť teórie je zameraná na potenciálne budúce antituberkuloticky pôsobiace látky. V tretej časti sú spomenuté ciele, na ktoré by sa mali zamerať nové antituberkulotiká a v štvrtej časti sú stručne zhrnuté súčasne používané látky v terapii tuberkulózy. Experimentálna časť sa sústreďuje na syntézu nasledujúcich zlúčenín: 5-(3-brómbenzylidén)-2-tioxo-1,3-tiazolidín-4-ónu, 5-(2-brómbenzylidén)-2- tioxo-1,3-tiazolidín-4-ónu, 5-(3-chlórbenzylidén)-2-tioxo-1,3-tiazolidín-4-ónu, 5- (2-chlórbenzylidén)-2-tioxo-1,3-tiazolidín-4-ónu, 5-(4-fluórbenzylidén)-2-tioxo- 1,3-tiazolidín-4-ónu, 5-(3-fluórbenzylidén)-2-tioxo-1,3-tiazolidín-4-ónu, 5-(2- fluórbenzylidén)-2-tioxo-1,3-tiazolidín-4-ónu, 5-(pyridín-4-ylmetylidén)-2-tioxo- 1,3-tiazolidín-4-ónu, 5-(pyridín-3-ylmetylidén)-2-tioxo-1,3-tiazolidín-4-ónu, 5- (furán-2-ylmetylidén)-2-tioxo-1,3-tiazolidín-4-ónu. Tieto látky boli testované na antifungálnu a antibakteriálnu aktivitu.
Institution: Charles University Faculties (theses)
(web)
Document availability information: Available in the Charles University Digital Repository. Original record: http://hdl.handle.net/20.500.11956/27782