Original title: Transkarbam 12 a transdermální průnik kofeinu z oleokrémů. 2.
Translated title: Transkarbam 12 and caffeine transdermal permeation from oleocreams. 2.
Authors: Dvořáková, Pavla ; Doležal, Pavel (referee) ; Berka, Pavel (advisor)
Document type: Master’s theses
Year: 2009
Language: cze
Abstract: [cze] [eng]
V teoretické cásti byla prehledne zpracována problematika kuže jako bariéry a problematika akcelerantu transdermální permeace, zejména Transkarbamu 12 (T12). V další cásti diplomové práce byl hodnocen akceleracní úcinek ruzných koncentrací T12 na in vitro permeaci kofeinu pres prasecí kuži plné tlouštky z oleokrému s 30 % vodné fáze. U krému s 0%; 0,3%; 0,5%; 0,7% a 1% T12 byly zjišteny hodnoty prumerných fluxu kofeinu Jr 6,29 ± 0,90 μg.cm-2.h-1; 9,13 ± 0,95 μg.cm-2.h-1; 8,71 ± 1,91 μg.cm-2.h-1; 10,20 ± 3,25 μg.cm-2.h-1 a 7,06 ± 0,81 μg.cm-2.h-1. Klícová slova: Transkarbam 12, akceleranty transdermální permeace, kofein, oleokrém In theoretical part of this work, the skin barrier function and transdermal permeation enhancers (with focus on Transkarbam 12, T12) were reviewed. In following experimental part, the acceleration effect of various concentrations of Transkarbam 12 (T12) on in vitro caffeine permeation through full-thickness pig ear skin was evaluated. Caffeine was administered in oleocreams containing 30 % aqueous phase. The values of mean flux of caffeine Jr from creams containing 0%; 0,3%; 0,5%; 0,7% and 1% T12 were 6,29 ± 0,90 μg.cm-2.h-1; 9,13 ± 0,95 μg.cm-2.h-1; 8,71 ± 1,91 μg.cm 2.h-1; 10,20 ± 3,25 μg.cm-2.h-1 and 7,06 ± 0,81 μg.cm-2.h-1 respectively. Keywords: Transkarbam 12, transdermal permeation enhancers, caffeine, oleocream

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/27735

Permalink: http://www.nusl.cz/ntk/nusl-282929


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Master’s theses