Original title: Kvantifikace v deskriptivním a experimentálnímstudiu funkční morfologie cévní stěny
Translated title: Quantification in descriptive and experimental study of functional
Authors: Tonar, Zbyněk ; Kočová, Jitka (advisor) ; Hach, Petr (referee) ; Míšek, Ivan (referee) ; Křen, Jiří (referee)
Document type: Doctoral theses
Year: 2007
Language: cze
Abstract: [cze] [eng]
Univerzita Karlova v Praze Lékařská fakulta v Plzni Ústav histologie a embryologie Kvantifikace v deskriptivním a experimentálním studiu funkční morfologie cévní stěny Quantification in descriptive and experimental study of functional morphology of vascular wall Autoreferát dizertační práce MUDr. Mgr. Zbyněk Tonar Plzeň 2007 Dizertační práce byla vypracována na Ústavu histologie a embryologie Lékařské fakulty Univerzity Karlovy v Plzni v rámci prezenční formy studia doktorského studijního programu v oboru všeobecné lékařství, specializace anatomie, histologie a embryologie. Uchazeč: MUDr. Mgr. Zbyněk Tonar odborný asistent Ústavu histologie a embryologie Karlovarská 48 301 66 Plzeň Školitel: Doc. MUDr. Jitka Kočová, CSc. Ústav histologie a embryologie Karlovarská 48 301 66 Plzeň Školitel specialista: Prof. Ing. Rudolf Poledne, CSc. Laboratoř pro výzkum aterosklerózy Institut klinické a experimentální medicíny Vídeňská 1958/9 140 21 Praha 48 Oponenti: Doc. MUDr. Petr Hach, CSc. Prof. Ing. Jiří Křen, CSc. Prof. MVDr. Ivan Míšek, CSc. Datum odevzdání práce: 10. 4. 2007 Autoreferát byl rozeslán dne: . . . . . . . . . 2007 Předseda oborové rady pro doktorský studijní program v oboru anatomie, histologie a embryologie: Doc. MUDr. Jitka Kočová, CSc. vedoucí Ústavu histologie a embryologie LF UK v Plzni Stanovisko k... Dissertation abstract The dissertation thesis consists of seventeen papers dealing with quantitative histological assessment of vascular wall and with application of morphometry in atherosclerosis research as well as in biomechanics of elastic arteries. History of microscopic morphometry with an emphasis on stereology is reviewed in the Introduction. The principles of mathematical morphology and of stereological estimation of volume, surface, area, length, and numerical density of objects in tissue blocks are explained in the Methods. The key rules of unbiased sampling of histological series and designing morphometric studies are summarized. The distribution of the overall observed variance in biological experiments, its sources and management are discussed. Procedures necessary for three-dimensional reconstructions based on scanned histological series are described. We proved that inflammatory process was significant in patients with ruptured aneurysm of abdominal aorta (AAA). There were more pronounced inflammatory infiltrates in areas of neovascularization in ruptured AAA than in asymptomatic AAA patients. Histological findings were in agreement with higher cytosol cytokine levels (IL-6, IL-8, TNF-α), enhanced collagen III metabolism and degradation in ruptured AAA. We found lower volume fraction of the...

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/10828

Permalink: http://www.nusl.cz/ntk/nusl-282256


The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses