Original title: Deriváty pyrazinu jako potenciální léčiva IV
Translated title: Pyrazine derivates as potential drugs IV.
Authors: Schürger, Oliver ; Doležal, Martin (advisor) ; Miletín, Miroslav (referee)
Document type: Master’s theses
Year: 2007
Language: slo
Abstract: [eng] [cze]
Oliver Schürger: Pyrazine derivates as potential drugs IV. Keywords : tuberculosis, Mycobacterium tuberculosis, Directly Observed Treatment Strategy, Multi drug Resistence, pyrazinamide Abstract of Diploma Thesis: This review is about worldwide problem of tuberculosis and about new trends in its treatment. Also chemical search about methods of preparing substituted amides of pyrazinecarboxylic acid and pyrazine-2,5-dinitril was done. All products were characterized by melting point, TLC, elemental analysis, IR analysis, log P and some of the final products have also 1 H, 13 C NMR spectra made. Products were not been tested in biological studies yet. Oliver Schürger: Deriváty pyrazínu ako potenciálne liečivá IV. Kľúčové slová : tuberkulóza, Mycobacterium tuberculosis, Directly Observed Treatment Strategy, Multi Drug Resistance, pyrazinamid, Abstrakt: V rámci diplomovej práce som vypracoval rešeršu zameranú na súčasný význam tuberkulózy vo svete a na najnovšie trendy v terapii. V chemickej literatúre som zisťoval metódy prípravy substituovaných amidov pyrazínkarboxylovej kyseliny, prípadne substituovaných pyrazín-2,5-dinitrilov Nasyntetizoval som desať doposiaľ nepopísaných látok charakteru substituovaných amidov pyrazínkarboxylovej kyseliny a substituovaných pyrazín- 2,5-dinitrilov Všetky produkty boli charakterizované teplotou topenia, TLC, elementárnou analýzou, IČ, log P u niektorých aj 1 H, 13 C NMR spektrami. Látky zatiaľ neboli podrobené in vitro biologickému hodnoteniu.

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/10619

Permalink: http://www.nusl.cz/ntk/nusl-279044


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Master’s theses