Original title: Chirurgická léčba diabetického makulárního edému
Translated title: Surgical treatment of diabetic macular edema
Authors: Aboutable, Tarek ; Kalvodová, Bohdana (advisor) ; Korda, Vladimír (referee) ; Boguszaková, Jarmila (referee)
Document type: Doctoral theses
Year: 2006
Language: eng
Abstract: Diabetic macular edema is the most common cause of visual impairment in diabetic patients. Precise pathophysiology of diabetic macular edema is unclear and seems to be multifactorial and includes pericyte loss, microaneurysm formation, basement membrane thickening and focal closure of the capillary bed, vitreomacular traction, and ultimately breakdown of the blood-retinal barrier with increased vascular permeability. Risk factors for clinical significant diabetic macular edema are hyperglycemia, hypertension, hyperlipidemia, duration of diabetes, and pregnancy. The increasing number of individuals with diabetes worldwide suggests that diabetic macular edema will continue to be major contributors to vision loss and associated functional impairment in the working-age population of most developed countries. Although eyes with diffuse macular edema carry a particularly poor prognosis despite laser photocoagulation, laser treatment is still the first choice of treatment for diabetic macular edema as it is safety and less invasive that other surgical options. Diffuse diabetic macular edema is characterized by diffuse leakage from extensive areas of the posterior retinal capillary bed, a scarcity of hard exudates, and often the formation of cystoid spaces. Focal macular edema, in contrast, is characterized by...

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/3369

Permalink: http://www.nusl.cz/ntk/nusl-266099


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses