Original title: Calcium signalling and gene regulation by carcinogenic Orai mutants
Authors: LITVIŇUKOVÁ, Monika
Document type: Master’s theses
Year: 2016
Language: eng
Abstract: The main objective of this work is to define and characterize point mutations of the calcium channel Orai isolated form the large scale cancer genomic dataset. Those mutats were examined in the means of sub-cellular localization as well as functionality. Out of 17 investigated mutations, 5 were found to alter protein gating and switch the channel to partially or fully open state. Altered gating then leads to impaired signalling and uncontroled transcription.
Citation: LITVIŇUKOVÁ, Monika. Calcium signalling and gene regulation by carcinogenic Orai mutants. České Budějovice, 2016. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/45157

Permalink: http://www.nusl.cz/ntk/nusl-263279


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Master’s theses