Original title: Characterisation of novel serpin TILIr and its relatives from the superfamily of serine protease inhibitors from \kur{Ixodes ricinus} tick
Authors: SLABÁ, Hana
Document type: Master’s theses
Year: 2016
Language: eng
Abstract: [eng] [cze]
Novel gene, named TILIr ( TIL Ixodes ricinus), that encoded yet unknown protein with TIL domain characteristic to proteins that belong to trypsin inhibitors family was discovered and isolated from hard tick Ixodes ricinus. Two isoforms of novel gene were identified and studied in this project. As the result of this study recombinant TILIr protein was produced in bacterial expression system and analysis of its functional characteristics was conducted. The protein belonging to family of trypsin inhibitors represent a potential candidate for anti-tick vaccine component. Tato práce pojednává o nově objeveném genu z klíštěte Ixodes ricinus, pojmenovaném TILIr (TIL Ixodes ricinus). Protein obsahuje TIL doménu a patří mezi inhibitory trypsinu. Spolu s TILIrem byly analyzovány dvě jeho isoformy. Výsledkem práce byla produkce rekombinantního proteinu v bakteriálním expresním vektoru a jeho funkční analýza. Protein, patřící do rodiny inhibitorů trypsinu, představuje potenciálního kandidáta pro komponentu protiklíštěcí vakcíny.
Keywords: inhibitory trypsinu; Ixodes ricinus; serpiny; TILIr
Citation: SLABÁ, Hana. Characterisation of novel serpin TILIr and its relatives from the superfamily of serine protease inhibitors from \kur{Ixodes ricinus} tick. České Budějovice, 2016. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/39992

Permalink: http://www.nusl.cz/ntk/nusl-262719


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Master’s theses