Original title: The Interplay Between the Notch Signaling Pathway and Cellular Metabolism
Authors: SLANINOVÁ, Věra
Document type: Doctoral theses
Year: 2016
Language: eng
Abstract: We identified four metabolic genes as direct targets of Notch signaling pathway both in vitro and in vivo and investigated the hypothesis that Notch directed metabolic changes support the growth of the imaginal wing dics. Vice versa, we observed the influence of metabolic changes on the activity of Notch signaling pathway and we identified Sirt1 as a metabolic sensor for the Notch pathway that helps to elicit an efficient response to Notch signal, in a metabolism sensitive manner.
Keywords: growth; metabolic sensors; metabolism; Notch; sirt1
Citation: SLANINOVÁ, Věra. The Interplay Between the Notch Signaling Pathway and Cellular Metabolism. České Budějovice, 2016. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/30999

Permalink: http://www.nusl.cz/ntk/nusl-262661


The record appears in these collections:
Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses