Original title: Screening of the health risks of biofilms using a battery of in vitro toxicity assays
Authors: Bláha, Luděk ; Babica, P. ; Sabatier, S. ; Admiraal, W. ; Maršálek, Blahoslav
Document type: Papers
Conference/Event: Regional Meeting of the Central and Eastern European Section /7./, Brno (CZ), 2002-10-14 / 2002-10-16
Year: 2002
Language: eng
Abstract: Traces of microcystin-lika compounds were detected by HPCL in biofilm samples from Netherlands. Half of the tested samples had no significant effect in any of the in vitro assays, other biofilms elicicted weak inhibitory/toxic effects mostly in high concentrations, which are not environmentally relevant. Most of observed weak effect seem to be associated with oxidative stress, an important toxicologicalĺmechanisms, as detected by depletion of intracellular antioxidantĺGHS by several biofilm samples. Potential adverse effects ofĺexterne polutants, which are known to accumulate in theĺperyphyton biomass should not underestimated. Mutagenicity andĺneurotoxicity of biofilm metabolits seems to be negligible. Weekĺadverse effects of biofilm extracts detected in a batery of inĺvitro assays indicate relatively low human health risksĺassociated with biofilm toxicity.
Keywords: HCPL; microcystin
Project no.: CEZ:AV0Z6005908 (CEP), KSK6005114 (CEP), EVKI-CT-1999-00001
Funding provider: GA AV ČR, BIOFILMS
Host item entry: SECOTOX 2002: Trends and advances in environmental chemistry and ecotoxicology, ISBN 80-210-2971-4

Institution: Institute of Botany AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0027734

Permalink: http://www.nusl.cz/ntk/nusl-21746


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