Original title: Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action
Authors: Bláha, L. ; Vondráček, Jan ; Upham, B. L. ; Machala, M.
Document type: Papers
Conference/Event: SECOTOX 2002. Regional Meeting of the Central and Eastern European Section /7./, Brno (CZ), 2002-10-14 / 2002-10-16
Year: 2002
Language: eng
Abstract: The aims of the present study were to determine potencies of a series of environmentally relevant PCB congeners to inhibit GJIC invitro, and to screen for intrcellular signaling pathways potentially involved in GJIC downregulation by PCBs. It was found that a number of nonplanar PCB congeners are efficient inhibitors of GJIC in vitro, and that a model compound, PCB153, does not act via activation of PKC or ERK1/2, which is contrast with the effects of protoypical inhibitors of GJIC, such as TPA or EGF.
Keywords: GJIC inhibition; PCBs; tumor promotion
Project no.: QC0194 (CEP), GA525/00/D101 (CEP)
Funding provider: GA MZe, GA ČR
Host item entry: SECOTOX 2002. Regional Meeting of the Central and Eastern European Section /7./ Book of Abstracts

Institution: Institute of Biophysics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0025046

Permalink: http://www.nusl.cz/ntk/nusl-21523


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Research > Institutes ASCR > Institute of Biophysics
Conference materials > Papers