Original title: Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system
Authors: PALUS, Martin
Document type: Rigorous theses
Year: 2015
Language: eng
Abstract: To address the underlying factors involved in development of tick-borne encephalitis (TBE) we developed an animal model of TBE based on BALB/c-c-STS/A (CcS/Dem) recombinant congenic mouse strains showing different severities of the infection in relation to the host genetic background. TBE virus growth, neutralizing antibody response, key cytokine and chemokine mRNA production and changes in mRNA levels of cell surface markers of immunocompetent cells in brain were measured in mice with different susceptibilities to TBE virus infection. Generated data indicate that the genetic control is an important factor influencing the clinical course of TBE.
Keywords: neuroinflammation; recombinant congenic mouse strains; tick-borne encephalitis
Citation: PALUS, Martin. Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system . České Budějovice, 2015. rigorózní práce (RNDr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/43976

Permalink: http://www.nusl.cz/ntk/nusl-188955


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Rigorous theses