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Original title:
Cytotoxické působení sinicových metabolitů na vybrané lidské rakovinné linie se zaměřením na pankreatickou linii PaTu
Translated title: Cytotoxic effect of some cyanobacterial crude extracts and metabolites against selected human cancer lines, especially focusing on pancreatic cancer cell line PaTu
Authors: VICKOVÁ, Kateřina
Document type: Bachelor's theses
Year: 2015
Language: cze
Abstract: Cancer is disease that affects human population for many thousands of years. Fortunately fighting cancer is more and more effective. This is mainly thanks to combining different strategies of therapy and progress in novel drug development and research. Cyanobacteria are emerging as an important source of novel bioactive secondary metabolites which provides an opportunity for new drug discovery. The aim of this study was evaluation of three cyanobacterial strains for in vitro cytotoxicity against human cancer cell lines, with special focus on pancreatic cancer cells. Crude extracts and chromatographic fractions were tested for their possible use (effectiveness) as selective cytotoxic and/or pro-apoptotic agents. Probably novel compound with anti-proliferative activity was found and isolated by HPLC-MS techniques.
Keywords: apoptosis; Cyanobacteria; human cancer cell lines; secondary metabolites; apoptóza; lidské rakovinné buněčné linie; sekundární metabolity; sinice
Citation: VICKOVÁ, Kateřina. Cytotoxické působení sinicových metabolitů na vybrané lidské rakovinné linie se zaměřením na pankreatickou linii PaTu. České Budějovice, 2015. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/41044
Permalink: http://www.nusl.cz/ntk/nusl-188257
The record appears in these collections:
Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Bachelor's theses
Translated title: Cytotoxic effect of some cyanobacterial crude extracts and metabolites against selected human cancer lines, especially focusing on pancreatic cancer cell line PaTu
Authors: VICKOVÁ, Kateřina
Document type: Bachelor's theses
Year: 2015
Language: cze
Abstract: Cancer is disease that affects human population for many thousands of years. Fortunately fighting cancer is more and more effective. This is mainly thanks to combining different strategies of therapy and progress in novel drug development and research. Cyanobacteria are emerging as an important source of novel bioactive secondary metabolites which provides an opportunity for new drug discovery. The aim of this study was evaluation of three cyanobacterial strains for in vitro cytotoxicity against human cancer cell lines, with special focus on pancreatic cancer cells. Crude extracts and chromatographic fractions were tested for their possible use (effectiveness) as selective cytotoxic and/or pro-apoptotic agents. Probably novel compound with anti-proliferative activity was found and isolated by HPLC-MS techniques.
Keywords: apoptosis; Cyanobacteria; human cancer cell lines; secondary metabolites; apoptóza; lidské rakovinné buněčné linie; sekundární metabolity; sinice
Citation: VICKOVÁ, Kateřina. Cytotoxické působení sinicových metabolitů na vybrané lidské rakovinné linie se zaměřením na pankreatickou linii PaTu. České Budějovice, 2015. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/41044
Permalink: http://www.nusl.cz/ntk/nusl-188257
The record appears in these collections:
Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Bachelor's theses
Record created 2015-06-11, last modified 2023-01-15