Original title: FoF1-ATP synthase/ATPase in the parasitic protist, \kur{Trypanosoma brucei}
Translated title: FoF1-ATP synthase/ATPase in the parasitic protist, \kur{Trypanosoma brucei}
Authors: ŠUBRTOVÁ, Karolína
Document type: Doctoral theses
Year: 2015
Language: cze
Abstract: This thesis primarily focuses on the FoF1-ATP synthase/ATPase complex in the parasitic protist, Trypanosoma brucei. Instead of its normal aerobic function to synthesize ATP, it is required to hydrolyze ATP to maintain the m in the infective bloodstream stage of T. brucei and the related parasite, T. b. evansi. To better understand the composition, structure and function of this druggable target, my work focused on deciphering the function of three of the unique Euglenozoa specific subunits that comprise this complex molecular machine. Furthermore, the ADP/ATP carrier, which provides substrates for the FoF1-ATP synthase/ATPase, was functionally characterized and evaluated if it is physically associated with the complexes of the oxidative phosphorylation pathway.
Keywords: ADP/ATP carrier; energy metabolism; FoF1-ATP synthase; FoF1-ATPase; oxidative phosphorylation; Trypanosoma brucei; Trypanosoma brucei evansi; ADP/ATP carrier; energy metabolism; FoF1-ATP synthase; FoF1-ATPase; oxidative phosphorylation; Trypanosoma brucei; Trypanosoma brucei evansi
Citation: ŠUBRTOVÁ, Karolína. FoF1-ATP synthase/ATPase in the parasitic protist, \kur{Trypanosoma brucei}. České Budějovice, 2015. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/18132

Permalink: http://www.nusl.cz/ntk/nusl-187469


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses